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April 25, 2024

Effect of chemical substances on hearing: interactions with noise

Abstract

While noise is the main cause of occupational deafness, certain chemical substances can produce ototoxic effects that may make the ear more prone to acoustic assault, as opposed to noise alone. They are mainly solvents, asphyxiants, metals and pesticides, widespread in workplaces. In Quebec, over 400,000 workers are exposed to high noise levels, which raises concerns regarding the prevention of hearing impairments. After having evaluated the effects of chemical substances alone on hearing, this time, researchers will analyze literature data to characterize the interactions between these chemical substances and noise, at exposure levels respecting the current standards of the Regulation respecting occupational health and safety. The results of this study will make it possible to determine the ototoxic agents that are most likely to interact with noise and to propose prevention strategies to stakeholders that take into account the additivity risk of the effects on hearing in situations of simultaneous exposure.

Produced Under this Project

  • Occupational ototoxicity of ethyl benzene (Poster)

    Vyskocil A., Leroux T., Truchon G., Lemay F., Gagnon F., El Majidi N., Viau C.

    Source :

    in Proceedings of the 29th International Congress on Occupational Health / ICOH, (29th : March 22-27, 2009 : Cape Town, South Africa), 2009

  • The assessment of the ototoxic potential of ethyl benzene

    Vyskocil A., Leroux T., Truchon G., Lemay F., Gendron M., Gagnon F., El Majidi N., Viau C.

    Source :

    in Toxicology Letters - Eurotox 2009 : 46th Congress of The European Societies of Toxicology (46th : September 13-16, 2009 : Dresden, Germany), vol. 189, suppl. 1, 2009, p. S257

  • Assessment of hearing dysfunction induced by industrial chemicals in presence or absence of noise: a weight of evidence approach (Poster)

    Vyskocil A., Lemay F., Leroux T., Gagnon F., Gendron M., Boudjerida A., Truchon G., El Majidi N., Lim S., Viau C.

    Source :

    in British Toxicology Society Annual Congress / BTS, (March 28-31, 2010 : Edinburgh, Scotland), 2010

  • The weight of evidence approach in the case of ototoxic chemicals

    Leroux T., Vyskocil A., Truchon G., Gendron M., Lemay F., Lim S., Gagnon F., Viau C.

    Source :

    in Annual Hearing Conservation Conference : Explore the World of Hearing Loss Prevention / NHCA 2010 (35th : February 27-27, 2010 : Orlando, USA), 2010

  • Ototoxic effects of industrial chemicals alone or in combination with noise

    Vyskocil A., Lemay F., Leroux T., Gagnon F., Gendron M., Boudjerida A., Truchon G., Lim S., Viau C.

    Source :

    in Health, Work and Social Responsibility : IOHA 2010 : International Scientific Conference (8th : September 28 - October 2, 2010 : Roma, Italy), 2010

  • A weight of evidence approach for the assessment of the ototoxic potential of industrial chemicals

    Vyskocil A., Truchon G., Leroux T., Lemay F., Gendron M., Lim S., Gagnon F., Viau C.

    Source :

    Toxicology and Industrial Health, vol. 28, no 9, 2012, p. 796-819

  • The weight of evidence approach in the assessment of hearing impairment induced by noise and ototoxic chemicals

    Leroux T., Vyskocil A., Truchon G., Lemay F., Gagnon F., Gendron M., Boudjerida A., El-Majidi N., Viau C.

    Source :

    in Proceedings of the 10th International Congress on Noise as a Public Health Problem / ICBEN 2011, (10th : July 24-28, 2011 : London, UK), 2011

Additional Information

Type: Project
Number: 0099-7450
Status: Completed
Year of completion: 2010
Team:
  • Adolf Vyskocil (Université de Montréal)
  • Ginette Truchon (IRSST)
  • Tony Leroux (Université de Montréal)
  • Claude Viau (Université de Montréal)