Evaluation of beryllium toxicity as a function of its chemical form and particle size Abstract In recent years, numerous authors have been questioning the level of protection offered to workers by the recognized threshold value for beryllium (Be) and its salts. The authors wanted to verify, using an animal model, to what extent pulmonary effects are related to the chemical form of Be and the size of its particles. The results obtained demonstrate numerous correlations between tissue concentrations of Be and pulmonary effects similar to those observed in a worker following exposure. The results also reveal an association between particle size, lung concentrations, pulmonary inflammation, the production of certain cytokines, and the expression of certain lymphocytes. The effects also depend on the chemical form of Be. Obviously, aerodynamic diameter and solubility played a significant role in pulmonary deposition and retention.The results of this study contribute to the understanding of the role of particle size and chemical form in the toxicity of Be. As well, they help to guide preventive actions relating to Be exposure, possibly including review of the exposure limit and the establishment of limit values as a function of chemical form and particle size. Produced Under this Project Scientific Reports Evaluation of beryllium toxicity based on the chemical form and particle size Research Report: R-637, R-750 Scientific Publications Particle size and beryllium toxicitySalehi F., Mazer B., Müller C., Chevalier G., Truchon G., Philippe S., Cloutier Y., Zayed J. Source : in 7th International Symposium on Biological Monitoring in Occupational & Environmental Health (7th : September 10-12, 2007 : Beijing, China), 2007Immunological responses in C3H/HeJ mice following nose-only inhalation exposure to different sizes of beryllium metal particlesSalehi F., Zayed J. , Audusseau S., Müller C., Truchon G., Plamondon P., L'Espérance G., Chevalier G., Mazer B.Source : Journal of Applied Toxicology, vol. 29, no 1, 2009, p. 61-68Beryllium toxicity assessment according to chemical specie and particle sizeMüller C., Mazer B., Truchon G., L'Espérance G., Chevalier G., Philippe S., Cloutier Y., Salehi F., Zayed J. Source : in 3rd International Conference on Beryllium Diseases, (3rd : October 16-19, 2007 : Philadelphia, Pennsylvania), 2007, Development of a murine model for assessment of chronic beryllium diseaseSalehi F., Audusseau S., Karp N., Zayed J. , Mazer B.Source : in Annual Meeting of the American Academy of Allergy Asthma & Immunology / AAAAI, (February 23-27, 2007 : San Diego, U.S.A.), 2007, no 408Développement, validation et application de méthodes d'analyse d'ultra-trace de béryllium dans des matrices biologiquesPaquette V., Larivière P., Truchon G., Van Tra H.Source : in XIe Colloque annuel des étudiants-chercheurs en chimie et biochimie de l'UQAM (11e : 30 avril, 2008 : Montréal, Canada), UQAM, 2008Développement, validation et application de méthodes d’analyse d’ultra-trace de béryllium dans des matrices biologiquesPaquette V., Larivière P., Cormier D., Truchon G., Zayed J. , Van Tra H.Source : in Recherche en santé et sécurité du travail en action : méthodes, résultats et applications : Congrès en santé et sécurité du travail / ACRST-RRSSTQ, (15-17 juin, 2008 : Montréal, Canada), 2008Monitoring of the contamination and human exposure to beryllium during an inhalation toxicology studyMüller C., Salehi F., Mazer B., Audusseau S., Truchon G., Chevalier G., Zayed J. Source : in Beryllium Health and Safety Committee Spring Meeting, (April 15-17, 2008 : Bethesda, U.S.A.), 2008 Immunological responses in a murine model following inhalation exposure to Be Metal, BeO, and AlBe particlesSalehi F., Audusseau S., Zayed J. , Mazer B.Source : in Annual Meeting of the American Academy of Allergy Asthma & Immunology / AAAAI, (March 14-18, 2008 : Philadelphia, U.S.A.), 2008Evaluation of a methodology for controlling beryllium exposure in laboratory settingMüller C., Audusseau S., Salehi F., Truchon G., Chevalier G., Mazer B., Zayed J. Source : in Society of Toxicology Annual Meeting and ToxExpo (48th : March 15-19, 2009 : Baltimore, United States), 2009Assessment of hair and bone accumulation of beryllium by mice exposed to contaminated dustsDrolet-Vives K., Zayed J. , Sauvé S.Source : Journal of Applied Toxicology, vol. 29, no 7, 2009, p. 638-642Beryllium contamination and exposure monitoring in an inhalation laboratory settingMüller C., Audusseau S., Salehi F., Truchon G., Chevalier G., Mazer B., Kennedy G., Zayed J.Source : Toxicology and Industrial Health, vol. 26, no 1, 2010, p. 39-45Urinary levels, tissue concentrations and lung inflammation after nose-only exposure to three different chemical forms of berylliumMüller C., Mazer B., Salehi F., Audusseau S., Chevalier G., Truchon G., Larivière P., Paquette V., Lambert J., Zayed J.Source : Journal of Applied Toxicology, vol. 30, no 5, 2010, p. 411-415Immunotoxicity of 3 chemical forms of beryllium following inhalation exposureMüller C., Salehi F., Mazer B., Audusseau S., Bouchard M., Adam-Poupart A., Chevalier G., Truchon G., Lambert J., Zayed J.Source : International Journal of Toxicology, vol, 30, no 5, 2011, p. 538-545Tissue concentrations and immunological effects in C3H/HeJ mice following an inhalation exposure to two particles size of Be and BeAlAdam-Poupart A., Müller C., Salehi F., Mazer B., Cloutier Y., Chevalier G., Truchon G., Lambert J., Larivière P., Paquette V., Zayed J.Source : in Annual Meeting of the Society of Toxicology, (50th : March 6-10, 2011 : Washington, USA), 2011 Additional Information Type: Project Number: 0099-3200 Status: Completed Year of completion: 2010 Research Field: Chemical and Biological Hazard Prevention Team: Joseph Zayed (Université de Montréal)Bruce Mazer (Université McGill)Gaston Chevalier (Université du Québec à Montréal )Ginette Truchon (IRSST)Gilles L'Espérance (Polytechnique Montréal)Suzanne Philippe (Université de Montréal)Pierre Larivière (IRSST)Yves Cloutier (IRSST)Lise Gareau (Université de Montréal)