IRSST - Institut de recherche Robert-Sauvé en santé et en sécurité du travail

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May 05, 2024

Quantification of biological variability – impact of variation in ambient contaminant levels

Abstract

Biomonitoring indicators serve as a complement to environmental monitoring for documenting, controlling and preventing worker exposure to chemical contaminants, and vary with factors related to the worker and his environment. In a previous study, the authors examined the individual conditions responsible for this variability. In this publication, they document the effect of variation in exposure levels on the measurement of these indicators. The objective: to propose a model for the mathematical calculation of the total variability while taking the different sources into account. As a complement to previous research in this field, this study provides Québec occupational health professionals with essential information on the total variability that can affect biomonitoring data. The results will be used to compare expected variations in environmental surveillance parameters to the variation in biological indicators, according to different exposure scenarios. This information will be added to the IRSST’s biomonitoring guide. The institute’s various clienteles will thus have a decision tool applicable to biomonitoring strategies. This research will also yield a computer tool that facilitates calculation of the number of samples required.

Produced Under this Project

  • Variabilité et surveillance biologique des travailleurs (Affiche)

    Nantel P., Tardif R., Truchon G., Charest-Tardif G., Droz P.-O., DeBatz A.

    Source :

    in Tendances et mouvances : Journées annuelles de santé publique, (9e : 14-17 novembre, 2005 : Québec, Canada), 2005

  • Quantification de la variabilité associée aux données de surveillance biologique de l’exposition

    Truchon G.

    Source :

    in Conférence du Centre de recherche TOXEN, (12 avril, 2007 : Montréal, Canada), 2007

  • Impact of biological and environmental variabilities on biological monitoring exposure

    Truchon G., Tardif R., Droz P. O., Batz A., Charest-Tardif G., Nantel P.

    Source :

    in Toxicology: Discovery Serving Society : 11th International Congress of Toxicology / ICT XI, (11th : July 15-19, 2007 : Montreal, Canada), CD-ROM, 2007, 1 p. (PT5.91)

  • A weight of evidence approach for the assessment of the ototoxic potential of industrial chemicals

    Vyskocil A., Truchon G., Leroux T., Lemay F., Lim S., Gagnon F., Viau C.

    Source :

    in Toxicology: Discovery Serving Society : 11th International Congress of Toxicology / ICT XI, (11th : July 15-19, 2007 : Montreal, Canada), CD-ROM, 2007, 1 p. (PT6.158)

  • Impact of biological and environmental variabilities on biological monitoring of occupational exposure - An approach using toxicokinetic models

    Berthet A., de Batz A., Tardif R., Charest-Tardif G., Truchon G., Vernez D., Droz P. O.

    Source :

    Journal of Occupational and Environmental Hygiene, vol. 7, no 3, 2010, p. 177-184

  • Evaluation of occupational exposure: comparison of biological and environmental variabilities using physiologically based toxicokinetic modeling

    Truchon G., Tardif R., Charest-Tardif G., De Batz A., Droz P.-O.

    Source :

    International Archives of Occupational and Environmental Health, vol. 86, no 2, 2013, p. 157-165

Additional Information

Type: Project
Number: 0099-2860
Status: Completed
Year of completion: 2007
Team:
  • Ginette Truchon (IRSST)
  • Pierre-Olivier Droz (Université de Lausanne)
  • Robert Tardif (Université de Montréal)
  • Thierry Petitjean-Roget (IRSST)