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NIOSH is the leading U.S. federal agency conducting research and providing guidance on the occupational safety and health implications and applications of nanotechnology. This research focuses NIOSH's scientific expertise, and its efforts, on answering questions essential to understanding nanotechnology implications and applications, such as the exposure of workers working in the manufacturing or industrial use of nanomaterials, the interactions between nanoparticles and the body's system as well as the effects that nanoparticles might have on the body's systems.