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OHS Research
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substance
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substance
August 27, 2025
Methylene bis (4-cyclohexylisocyanate)
French name in the regulation:
Diisocyanate-4,4' de dicyclohexylméthane
CAS :
5124-30-1
Synonyms:
Méthylène bis(4-cyclohexyl isocyanate)
Exposure Standards in RROHS regulation
Permissible exposure values (PEV)
ppm
mg/m
3
f/cc
Notes
TWAEV
0,005
0,054
-
-
STEV
-
-
-
-
Ceiling
-
-
-
-
Carcinogenicity
Sensitizer
S
Simple asphyxiant
Percutaneous
Prohibited use
Prohibited recirculation
Minimum exposure
Explosion hazard
Ototoxic
TWA adjustment for unusual work schedules
III
: Weekly adjustment
CNESST – Toxicological Index Service
Consult REPTOX file:
Methylene bis (4-cyclohexylisocyanate)
Analysis:
Diisocyanate-4,4' de dicyclohexylméthane (HMDI)
Method: IRSST - 376
Sampling protocol
Sampling device:
Sampling media required:
#IRSST
Description
917
Impregnated GF filter in series with teflon filter and vial
Parameters:
Flow rate: 1 L/min
TWA sampling volume: 15 L
STEL sampling volume: -
Remarks:
Refer to the sampling guidelines supplied with the equipment. HMDI must be sampled specifically.
Analytical protocol
Principle:
High performance liquid chromatography with UV detection (HPLC-UV)
Precision (%):
11
Remarks:
The two filters in the sampling cassette allow specific analysis of monomer HMDI in vapour form and in aerosol form. The result supplied in the report is the sum of the monomers of HMDI of the two fractions. Determination of the corresponding oligomers is also done during the analysis. The sampling time can be longer than 15 minutes if the HMDI is present in vapour form only. RMV for HMDI monomer vapour is 0.03 µg. RMV for HMDI monomer aerosol is 0.07 µg.
Reference
IRSST. "Détermination de la fraction monomèrique des isocyanates sous forme vapeur et aérosol dans l'air des lieux de travail". Méthode 376. Non publiée.
HMDI à haute sensibilité
Method: IRSST - 366
Sampling protocol
Sampling device:
Sampling media required:
#IRSST
Description
970
Impregnated GF filter
Parameters:
Flow rate: 1,0 L/min
TWA sampling volume: 15 L
STEL sampling volume: -
Remarks:
The recommended volume is 15 litres; however the sampling time can be up to 8 hours. Store the samples in a refrigerator before and after sampling.
Analytical protocol
Principle:
High performance liquid chromatography with mass spectrometry (HPLC-MS)
Precision (%):
4,9
Minimum reported value:
0,0015 µg
Remarks:
HMDI must be specifically sampled. The analysis is done for the isocyanate present in vapour form only and the result is expressed as a monomer concentration.
Reference
IRSST. "Analyse des isocyanates à haute sensibilité". Méthode 366. Non publiée.
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