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IRSST - Institut de recherche Robert-Sauvé en santé et en sécurité du travail
OHS Research
Research at the IRSST
Reference Framework
Scientists Directory
Publications and Tools
IRSST's Production
Magazine and Newsletter
Scientific Watch
Documentation Center
Useful Links
Laboratory Services
Laboratories
Analysis and Testing Services
Laboratory Methods
Masks Efficacy Evaluation
Workplace Air Contaminants
Slip Resistance Test for Protective Footwear
Loan, Calibration and Repairs
Recognition Programs
CQ Fibres
Quality Control of Fiber Counts
CQ Vrac
Recognized Laboratories
Interlaboratory quality
control program
Guides and Tools
Instruments and Sampling Material
Register
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substance
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substance
August 27, 2025
Hexamethylene diisocyanate
French name in the regulation:
Diisocyanate d'hexaméthylène
CAS :
822-06-0
Exposure Standards in RROHS regulation
Permissible exposure values (PEV)
ppm
mg/m
3
f/cc
Notes
TWAEV
0,005
0,034
-
-
STEV
-
-
-
-
Ceiling
-
-
-
-
Carcinogenicity
Sensitizer
S
Simple asphyxiant
Percutaneous
Prohibited use
Prohibited recirculation
Minimum exposure
Explosion hazard
Ototoxic
TWA adjustment for unusual work schedules
III
: Weekly adjustment
CNESST – Toxicological Index Service
Consult REPTOX file:
Hexamethylene diisocyanate
Analysis:
Diisocyanate d'hexaméthylène (HDI)
Method: IRSST - 376
Sampling protocol
Sampling device:
Sampling media required:
#IRSST
Description
917
Impregnated GF filter in series with teflon filter and vial
Parameters:
Flow rate: 1 L/min
TWA sampling volume: 15 L
STEL sampling volume: -
Remarks:
Refer to the sampling guidelines supplied with the equipment. For surface wipe test, contact Laboratory Customer Service.
Analytical protocol
Principle:
High performance liquid chromatography with UV detection (HPLC-UV)
Precision (%):
13
Remarks:
The two filters in the sampling cassette allow specific analysis of monomer isocyanate in vapour form and in aerosol form and the result of each form is supplied. It should be noted that only the result representing the sum of the two forms, also reported in the analytical report (total monomer), must be used for comparison to a PEV. Determination of the corresponding oligomers is also done during the analysis. The sampling time can be longer than 15 minutes if the isocyanate is present in vapour form only. IPDI can be determined simultaneously at HDI on the same sample. However, the analytical method does not differentiate HDI oligomers from IPDI oligomers. RMV for HDI monomer vapour is 0.014 µg. RMV for HDI monomer aerosol is 0.052 µg.
Reference
IRSST. "Détermination de la fraction monomèrique des isocyanates sous forme vapeur et aérosol dans l'air des lieux de travail". Méthode 376. Non publiée.
HDI à haute sensibilité
Method: IRSST - 366
Sampling protocol
Sampling device:
Sampling media required:
#IRSST
Description
970
Impregnated GF filter
Parameters:
Flow rate: 1,0 L/min
TWA sampling volume: 15 L
STEL sampling volume: -
Remarks:
The recommended volume is 15 litres; however the sampling time can be up to 8 hours. Store the samples in a refrigerator before and after sampling.
Analytical protocol
Principle:
High performance liquid chromatography with mass spectrometry (HPLC-MS)
Precision (%):
4,4
Minimum reported value:
0,0005 µg
Remarks:
Four isocyanates can be requested at the same time: HDI, TDI, MDI and IPDI. The analysis is done for the isocyanates present in vapour form only and the result is expressed as a monomer concentration.
Reference
IRSST. "Analyse des isocyanates à haute sensibilité". Méthode 366. Non publiée.
Diisocyanate d'hexaméthylène (HDI)
Method: IRSST - 376
Sampling protocol
Sampling device:
Sampling media required:
#IRSST
Description
1415
Glass midget Impinger for isocyantes
Parameters:
Flow rate: 1 L/min
TWA sampling volume: 15 L
STEL sampling volume: -
Remarks:
Refer to the sampling guidelines supplied with the equipment. For surface wipe test, contact Laboratory Customer Service. An impinger must be used for sampling if the process applied in the workplace involves a very fast isocyanate reaction, such as the application of MDI-based insulation for building insulation. Impinger sampling can only be done at a fixed station. Use equipment code 981 if small diameter particles are suspected (<2µm) and equipment code 1415 if only large particles are anticipated (>2µm). Determination of corresponding oligomers is also done during the analysis. The sampling time for impingers may be longer than 15 minutes.
Analytical protocol
Principle:
High performance liquid chromatography with UV detection (HPLC-UV)
Precision (%):
12
Minimum reported value:
0,026 µg
Remarks:
IPDI can be determined simultaneously at HDI on the same sample. However, the analytical method does not differentiate HDI oligomers from IPDI oligomers.
Reference
IRSST. "Détermination de la fraction monomèrique des isocyanates sous forme vapeur et aérosol dans l'air des lieux de travail". Méthode 376. Non publiée.
Diisocyanate d'hexaméthylène (HDI)
Method: IRSST - 376
Sampling protocol
Sampling device:
Sampling media required:
#IRSST
Description
981
Isocyanates glass midget impinger and filter
Parameters:
Flow rate: 1 L/min
TWA sampling volume: 15 L
STEL sampling volume: -
Remarks:
Refer to the sampling guidelines supplied with the equipment. For surface wipe test, contact Laboratory Customer Service. An impinger must be used for sampling if the process applied in the workplace involves a very fast isocyanate reaction, such as the application of MDI-based insulation for building insulation. Impinger sampling can only be done at a fixed station. Use equipment code 981 if small diameter particles are suspected (<2µm) and equipment code 1415 if only large particles are anticipated (>2µm). Determination of corresponding oligomers is also done during the analysis. The sampling time for impingers may be longer than 15 minutes.
Analytical protocol
Principle:
High performance liquid chromatography with UV detection (HPLC-UV)
Precision (%):
12
Minimum reported value:
0,026 µg
Remarks:
IPDI can be determined simultaneously at HDI on the same sample. However, the analytical method does not differentiate HDI oligomers from IPDI oligomers.
Reference
IRSST. "Détermination de la fraction monomèrique des isocyanates sous forme vapeur et aérosol dans l'air des lieux de travail". Méthode 376. Non publiée.
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