IRSST - Institut de recherche Robert-Sauvé en santé et en sécurité du travail

Toluene diisocyanate (TDI) (isomers mixture)

French name in the regulation: Diisocyanate de toluène (TDI) (mélange d'isomères)
CAS : 26471-62-5
Synonyms: Isocyanic acid, methyl-m-phenylene ester; Desmodur T100; Diisocyanatomethylbenzene; Methylphenylene isocyanate; Rubinate TDI

Exposure Standards in RROHS regulation

Permissible exposure values (PEV)
ppm mg/m3 f/cc Notes
TWAEV 0,005 0,036 - -
STEV 0,02 0,14 - -
Ceiling - - - -
Simple asphyxiant Percutaneous
Minimum exposure  Sensitizer
Prohibited use Prohibited recirculation
Carcinogenicity

TWA adjustment for unusual work schedules

III : Weekly adjustment

CNESST – Toxicological Index Service


Analysis:

Diisocyanate de toluène (TDI) (mélange d'isomères)

Method: IRSST - 376
Sampling device:
Sampling media required:
#IRSSTDescription
917 Impregnated GF filter in series with teflon filter and vial

Parameters:
Flow rate: 1 L/min
TWA sampling volume: 15 L
STEL sampling volume: -
Remarks: Refer to the sampling guidelines supplied with the equipment. For surface wipe test, contact Laboratory Customer Service.
Principle: High performance liquid chromatography with UV detection (HPLC-UV)
Remarks: The two filters in the sampling cassette allow specific analysis of monomer isocyanate in vapour form and in aerosol form. The result of each form is supplied. It should be noted that only the result representing the sum of the two isomers, (total monomer), must be used for comparison to a PEV. Determination of the corresponding oligomers is also done during the analysis. The sampling time can be longer than 15 minutes if the isocyanate is present in vapour form only. CVa for 2,4 TDI and 2,6 TDI total monomer are respectively 9.5% and 15%. RMV for 2,4 TDI and the 2,6 TDI monomer vapour is 0.015 µg. RMV for 2,4 TDI and the 2,6 TDI monomer aerosol is 0.025 µg.
IRSST. "Détermination de la fraction monomèrique des isocyanates sous forme vapeur et aérosol dans l'air des lieux de travail". Méthode 376. Non publiée.

TDI à haute sensibilité

Method: IRSST - 366
Sampling device:
Sampling media required:
#IRSSTDescription
970 Impregnated GF filter

Parameters:
Flow rate: 1,0 L/min
TWA sampling volume: 15 L
STEL sampling volume: -
Remarks: The recommended volume is 15 litres; however the sampling time can be up to 8 hours. Store the samples in a refrigerator before and after sampling.
Principle: High performance liquid chromatography with mass spectrometry (HPLC-MS)
Minimum reported value: 0,0005 µg
Remarks: Four isocyanates can be requested at the same time: HDI, TDI, MDI and IPDI. The analysis is done for the isocyanates present in vapour form only and the result is expressed as a monomer concentration. The results for 2,4 TDI and 2,6 TDI are given separately. CVa for 2,4 TDI and 2,6 TDI are respectively 4.2% and 3.7%.
IRSST. "Analyse des isocyanates à haute sensibilité". Méthode 366. Non publiée.

Diisocyanate de toluène (TDI) (mélange d'isomères)

Method: IRSST - 376
Sampling device:
Sampling media required:
#IRSSTDescription
1415 Glass midget Impinger for isocyantes

Parameters:
Flow rate: 1 L/min
TWA sampling volume: 15 L
STEL sampling volume: -
Remarks: Refer to the sampling guidelines supplied with the equipment. For surface wipe test, contact Laboratory Customer Service. An impinger must be used for sampling if the process applied in the workplace involves a very fast isocyanate reaction, such as the application of MDI-based insulation for building insulation. Impinger sampling can only be done at a fixed station. Use equipment code 981 if small diameter particles are suspected (<2µm) and equipment code 1415 if only large particles are anticipated (>2µm). Determination of corresponding oligomers is also done during the analysis. The sampling time for impingers may be longer than 15 minutes.
Principle: High performance liquid chromatography with UV detection (HPLC-UV)
Minimum reported value: 0,025 µg
Remarks: CVa for 2,4 TDI and 2,6 TDI total monomer are respectively 5.9% and 13%.
IRSST. "Détermination de la fraction monomèrique des isocyanates sous forme vapeur et aérosol dans l'air des lieux de travail". Méthode 376. Non publiée.

Diisocyanate de toluène (TDI) (mélange d'isomères)

Method: IRSST - 376
Sampling device:
Sampling media required:
#IRSSTDescription
981 Isocyanates glass midget impinger and filter

Parameters:
Flow rate: 1 L/min
TWA sampling volume: 15 L
STEL sampling volume: -
Remarks: Refer to the sampling guidelines supplied with the equipment. For surface wipe test, contact Laboratory Customer Service. An impinger must be used for sampling if the process applied in the workplace involves a very fast isocyanate reaction, such as the application of MDI-based insulation for building insulation. Impinger sampling can only be done at a fixed station. Use equipment code 981 if small diameter particles are suspected (<2µm) and equipment code 1415 if only large particles are anticipated (>2µm). Determination of corresponding oligomers is also done during the analysis. The sampling time for impingers may be longer than 15 minutes.
Principle: High performance liquid chromatography with UV detection (HPLC-UV)
Minimum reported value: 0,025 µg
Remarks: CVa for 2,4 TDI and 2,6 TDI total monomer are respectively 5.9% and 13%.
IRSST. "Détermination de la fraction monomèrique des isocyanates sous forme vapeur et aérosol dans l'air des lieux de travail". Méthode 376. Non publiée.
Following the amendment of Appendix 1 of the Quebec Regulation respecting occupational health and safety (RSST, RLRQ, c. S-2.1, r. 13), part of Quebec Occupational Health and Safety Act, which came into effect on March 26, 2020, the TWAEV, STEL and Ceiling values for certain substances are now expressed in ppm. For these substances, the IRSST performed the conversion calculations to express these TWAEV, TWA and Ceiling values in mg/m3, which thus appears in its Sampling Guide for Air Contaminants in the Workplace (Guide d'échantillonnage des contaminants de l'air en milieu de travail ) and the associated Substance Data Sheets. However, it is imperative to refer to the values expressed in the RSST which are legally binding.