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IRSST - Institut de recherche Robert-Sauvé en santé et en sécurité du travail
OHS Research
Research at the IRSST
Reference Framework
Scientists Directory
Publications and Tools
IRSST's Production
Magazine and Newsletter
Scientific Watch
Documentation Center
Useful Links
Laboratory Services
Laboratories
Analysis and Testing Services
Laboratory Methods
Masks Efficacy Evaluation
Workplace Air Contaminants
Slip Resistance Test for Protective Footwear
Loan, Calibration and Repairs
Recognition Programs
CQ Fibres
Quality Control of Fiber Counts
CQ Vrac
Recognized Laboratories
Interlaboratory quality
control program
Guides and Tools
Instruments and Sampling Material
Register
Research Fund and Partnerships
Research Fund and Partnerships
Grants
Scholarships
Master’s Scholarship and Supplement
Doctoral Scholarship and Supplement
Postdoctoral Fellowship
Research partnerships
Institute
About
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substance
September 16, 2025
4,4'-Methylene dianiline
French name in the regulation:
Diamino-4,4' diphénylméthane
CAS :
101-77-9
Synonyms:
Méthylène-4,4' dianiline
Exposure Standards in RROHS regulation
Permissible exposure values (PEV)
ppm
mg/m
3
f/cc
Notes
TWAEV
0,1
0,81
-
-
STEV
-
-
-
-
Ceiling
-
-
-
-
Carcinogenicity
C2
Sensitizer
Simple asphyxiant
Percutaneous
Prohibited use
Prohibited recirculation
Minimum exposure
Explosion hazard
Ototoxic
TWA adjustment for unusual work schedules
III
: Weekly adjustment
CNESST – Toxicological Index Service
Consult REPTOX file:
4,4'-Methylene dianiline
Analysis:
Diamino-4,4' diphénylméthane
Recommended method by the IRSST:
Method: NIOSH - 5029
Sampling protocol
Sampling device:
Glass fiber filter impregnated with sulfuric acid
Parameters:
Flow rate: 1-2 L/min
TWA sampling volume: 1000 L
STEL sampling volume: -
Remarks:
Immediately after sampling, transfer the filter to a vial containing a reactive solution. Contact the IRSST before sampling.
Analytical protocol
Principle:
High performance liquid chromatography with UV detection (HPLC-UV)
Reference
NIOSH Manual of Analytical Methods, 4th ed. Method 5029 : 4,4'-Dimethylenedianiline, 1994.
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