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Project IRSST
 | Studying the environmental and physiological factors contributing to biological variability: impact of workload on biological exposure indicatorsGinette Truchon
/ IRSST
Robert Tardif,
Phillip Gardiner,
Martin Brochu
/ Université de Montréal
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0099-1700 : Completed
A research program undertaken by the IRSST a few years ago showed that workload can have a major impact on the value of the biological exposure indicators (BEI) for various solvents. During a subsequent step, the researchers were able to better characterize this impact. Using volunteers, they studied in the laboratory the variations in the BEIs induced by different workloads for five industrial solvents and under exposure conditions similar to those prevailing in an industrial environment. For four of the five solvents studied (toluene, styrene, trichloroethylene and acetone), an increase in workload produced an increase in the biological exposure indicators, in contrast to n-hexane, whose BEIs remained stable. Physiologically-based toxicokinetic (PBTK) modeling, developed for each of the solvents, corroborates these results.
Designers of PBTK models now have equations resulting from probative physiological data that they can use to integrate variability in the workload into their model.
IRSST publicationsTardif, Robert; Charest-Tardif, Ginette; Truchon, Ginette; Brochu, MartinInfluence de la charge de travail sur les indicateurs biologiques d'exposition de cinq solvants
(Impact of workload on the biological exposure indicators for five solvents)
Études et recherches / Rapport
R-561, Montréal, IRSST, 2008, 56 pages. Free download
More Info
Scientific publications and communicationsNadeau V.,
Truchon G.,
Brochu M.,
Tardif R.
Effect of physical exertion on the biological exposure indices of various solvents following exposure by inhalation in human volunteers : I. Toluene
Journal of Occupational and Environmental Hygiene, vol. 3, no 9, 2006, p. 481-489.
Nadeau V.,
Truchon G.,
Brochu M.,
Tardif R.
Évaluation de l’impact exercé par la charge de travail sur les indicateurs biologiques d’exposition du toluène suite à des expositions par inhalation chez des volontaires
in La société des savoirs : 72e Congrès de l'Association canadienne-française pour l'avancement des sciences / ACFAS (72e : 10-14 mai, 2004 : Montréal, Canada), 2004.
Nadeau V.,
Truchon G.,
Brochu M.,
Tardif R.
Effect of workload on the kinetics of inhaled toluene in human volunteers
in American College of Sports Medicine Annual Meeting (51st : June 2-5, 2004 : Indianapolis, Indiana), 2004.
Nadeau V.,
Truchon G.,
Brochu M.,
Tardif R.
Effect of physical exertion on the biological exposure indices ot toluene following exposure by inhalation in human volunteers
in Proceedings of the Annual Meeting of the Society of Toxicology (43rd : March 21-25, 2004 : Baltimore, Maryland), 2004.
Tardif R.,
Truchon G.,
Bérubé A.,
Sari-Minodier I.,
Charest-Tardif G.
Modeling the impact of workload intensity on the biological exposure indicators of solvents
in International Congress of Toxicology / IUTOX (12th : July 19-23, 2010 : Barcelona, Spain), 2010.
Tardif R.,
Nadeau V.,
Truchon G.,
Brochu M.
Effect of physical exertion on the biological monitoring of exposure to various solvents following exposure by inhalation in human volunteers: II. n-Hexane
Journal of Occupational and Environmental Hygiene, vol. 4, no 7, 2007, p. 502-508.
Tardif R.,
Nadeau V.,
Truchon G.,
Charest-Tardif G.,
Brochu M.
Effect of physical exertion on the biological monitoring of exposure to solvents in human volunteers : 2. n-Hexane
in Proceedings of the 28th International Congress on Occupational Health / ICOH, (28th : June 11-16, 2006 : Milan, Italy), 2006.
Tardif R.,
Nadeau V.,
Truchon G.,
Charest-Tardif G.,
Brochu M.
Effect of physical exertion on the biological monitoring of exposure to solvents in human volunteers : 1. Toluene
in Proceedings of the 28th International Congress on Occupational Health / ICOH, (28th : June 11-16, 2006 : Milan, Italy), 2006.
Truchon G.,
Brochu M.,
Tardif R.
Effect of physical exertion on the biological monitoring of exposure to various solvents following exposure by inhalation in human volunteers: III. Styrene
Journal of Occupational and Environmental Hygiene, vol. 6, no 8, 2009, p. 460-467.
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