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Mixie: Mixtures of substances in the workplace: computer-based tool for evaluating the chemical risk (Calculation of the Rm)
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 Exposure to mixtures of chemical
substances in the workplace raises questions. Organizations such as the
ACGIH® in its Chemical Substance TLV® Committee and much
legislation make the recommendation that the presence of all the contaminants
that have similar effects on the same organs or systems of the human body be
taken into account. In this case, it is recommended that the exposures be added
rather than considered individually... unless it is established otherwise... the
interactions must then be taken into account (synergy, potentiation,
antagonism...).
The computer-based tool that you are preparing to
use integrates the results of a research project on toxicological interactions.
The project was carried out in 2 phases and the reports are available on the
IRSST’s Web site : ( Phase 1 et Phase 2 ).
Disclaimer
This computer-based tool is an aid in
decision-making made available to occupational health professionals. It informs
them about the additivity or interaction potential between chemical substances
in a mixture found in the workplace. It cannot
replace the informed judgement of an occupational health professional.
Adolf Vyskocil and Daniel Drolet
Access to the tool : (see
installation note below
)
Two versions of the tool are available.
Team
Project leaders
- Adolf Vyskocil, Département de santé
environnementale et de santé au travail, Université de Montréal
- Daniel Drolet, Institut de recherche Robert-Sauvé
en santé et en sécurité du travail du Québec
Software development
- François Lemay, Institut de recherche Robert-Sauvé
en santé et en sécurité du travail du Québec
Collaborators
- Claude Viau, Département de santé environnementale
et de santé au travail, Université de Montréal
- Gilles Lapointe, Service du répertoire
toxicologique, Commission de la santé et de la sécurité du travail du Québec
- Robert Tardif, Département de santé
environnementale et de santé au travail, Université de Montréal
- Ginette Truchon, Institut de recherche Robert-Sauvé
en santé et en sécurité du travail du Québec
- France Gagnon, Département de santé
environnementale et de santé au travail, Université de Montréal
- Normand Gagnon, Service du répertoire
toxicologique, Commission de la santé et de la sécurité du travail du Québec
- Marc Baril, Institut de recherche Robert-Sauvé en
santé et en sécurité du travail du Québec
- Denis Bégin, Département de santé environnementale
et de santé au travail, Université de Montréal
- Michel Gérin, Département de santé environnementale
et de santé au travail, Université de Montréal
Application of the Regulation
respecting occupational health and safety ( RROHS)
in Quebec Contrary to the utility for the adjustment of PEVs of the RROHS in
relation to unusual work schedules, the use of this utility is not
mandatory for applying the RROHS. Part 3 of Schedule 1 of the RROHS
mentions that ...
«Where two or more
substances… are present at the work location and where they have similar effects
on the same organs of the human body, the effects of these substances are
considered to be additive, unless it is established otherwise.» This
provision applies only for TWAEV (time-weighted average exposure values)
and not for short-term exposure values (STEV) or ceiling values (CV).
The Java version and the Javascript version both
require the use of a recent browser. The Javascript version
should operate properly as soon as Javascript is permitted at the computer
workstation from which the utility is invoked. This requirement also
applies to the Java version which, essentially a Java applet, requires as well
the prior installation of " Java Runtime Environment ( JRE)"
available from Sun at http://java.sun.com/products/plugin/. The
Java version allows up to 12 substances to be chosen, while the Javascript
version is limited to 8 substances.
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