Use of modelling to quantify biological variation : Production of a guide to biological monitoring strategies Abstract Due to the few tools and sometimes limited knowledge available, it is often difficult for workplace professionals to establish sampling strategies and to interpret the results of biological monitoring, mainly relating to the effect of variability on exposure indicator values. The authors did an exhaustive review of the documentation, modeled the toxicokinetics of contaminants in the human body, and did simulations and statistical analyses. They were able to quantify the variability of an entire series of biological exposure indicators and to specify the main factors in question. They propose a biological monitoring application framework adapted to the Québec context, covering the 25 substances listed in the IRSST’s biological monitoring guide, which will be revised in relation to the results. It is hoped that the outcome will be a more judicious use of this type of workplace monitoring, as a complement to environmental monitoring. Produced Under this Project Scientific Reports Quantification of biological variability using modeling - Development of a strategy guide for biological exposure monitoring Research Report: R-337 Simplified Articles Vers une utilisation plus judicieuse de la surveillance biologique Volume 17, n0 1 Scientific Publications Physiologically based toxicokinetic modelling of the interaction between n-hexane and toluene in rats and humansAli N., Tardif R.Source : Journal of Occupational Health, vol. 41, no 2, 1999, p. 95-103Impact of human variability on the biological monitoring of exposure to toluene. II. Compartmental based toxicokinetic modellingPierrehumbert G., Droz P. O., Tardif R., Charest-Tardif G., Truchon G.Source : Toxicology Letters, vol. 134, no 1-3, 2002, p. 165-175Impact of human variability on the biological monitoring of exposure to toluene. I. Physiologically based toxicokinetic modellingTardif R., Droz P. O., Charest-Tardif G., Pierrehumbert G., Truchon G.Source : Toxicology Letters, vol. 134, no 1-3, 2002, p. 155-163Une dose, plusieurs réponses!Truchon G., Tardif R.Source : Travail et santé, vol. 18, no 4, 2002, p. 37-40Impact of human variability on the biological monitoring of exposure to toluene: I. Physiologically-based toxicokinetic modellingTardif R., Droz P., Charest-Tardif G., Pierrehumbert G., Truchon G.Source : in 5th International Symposium on Biological Monotoring (5th : September 18-21, 2001 : Banff, Canada), 2001Impact of human variability on the biological monitoring of exposure to toluene: II. Compartmental based toxicokinetic modellingPierrehumbert G., Droz P., Tardif R., Charest-Tardif G., Truchon G.Source : in 5th International Symposium on Biological Monotoring (5th : September 18-21, 2001 : Banff, Canada), 2001Caractérisation de la variabilité affectant les indicateurs d'exposition du 1,1,1-trichloroéthane à l'aide de la simulation toxicocinétique à base physiologique: étude de sensibilité et simulation Monte-CarloHamelin G., Charest-Tardif G., Truchon G., Tardif R.Source : in Colloque CIRTOX (mai, 2002 : Montréal, Canada), 2002Contribution of toxicokinetic modeling to the study of the impact of human variability on the biological monitoring of exposure to industrial chemicalsTardif R., Droz P. O., Charest-Tardif G., Pierrehumbert G., Truchon G.Source : in X2004 "Exposure Assessment in a Changing Environment" (June 16-18, 2004 : Utrecht, The Netherlands), 2004, p. 97Variabilité biologique et interprétation des résultats de surveillanceTruchon G.Source : in Colloque annuel de l'Association des médecins du réseau public en santé au travail du Québec (Mai, 2002 : Montréal, Canada), 2002Impact of human variability on the biological monitoring of exposure to toluene. Physiologically based toxicokinetic modellingTardif R., Droz P. O., Charest-Tardif G., Pierrehumbert G., Truchon G.Source : in National Symposium of the Canadian Association for Research on Work & Health / CARWH (1st : November 18, 2001 : Toronto, Canada), 2001Biological exposure indicators: quantification of biological variability using toxicokinetic modelingTruchon G., Tardif R., Droz P.-O., Charest-Tardif G., Pierrehumbert G.Source : Journal of Occupational and Environmental Hygiene, vol. 3, no 3, 2006, p. 137-143Toxicokinetic modeling : a tool to better understand biomarker variabilityTardif R., Droz P.-O., Truchon G.Source : in Proceedings of the 28th International Congress on Occupational Health / ICOH, (28th : June 11-16, 2006 : Milan, Italy), 2006 Additional Information Type: Project Number: 0097-0990 Status: Completed Year of completion: 2003 Research Field: Chemical and Biological Hazard Prevention Team: Ginette Truchon (IRSST)Robert Tardif (Université de Montréal)Pierre-Olivier Droz (Université de Lausanne)Daniel Drolet (IRSST)