Abstract

The toxicity of a number of petrochemicals used in the production of plastic goods is unknown.

Several chemicals were administered to rats either orally, by inhalation, or by intra-abdominal injection. Kidney damage was assessed through urinalysis and biochemical and histological studies.

Toxic doses and renal effects were characterized for each substance. Administration of two products increases toxicity. No antagonistic effects were observed.

Exposure standards should be lowered for mixed exposures, although specific limits have to be determined on a case-by-case basis. Given the wide range and complexity of toxic effects observed, further work on preventive screening techniques is indicated.