Monitoring the exposure of machinists to carcinogenic compounds from the use of cooling liquids Abstract Cutting oils containing nitrosamines or generating nitrosamines during use are still used in some workplaces, despite American and Canadian regulations aiming at protecting workers against them; in fact approximately 25,000 metal workers regularly use such fluids. It is therefore important to develop measures to prevent absorption of these products. Analytical methods for nitrosamines were therefore refined or developed de novo, and are available upon request. Environmental and biological monitoring of nitrosamines used in cooling fluids was conducted in several factories. Nitrosamines were only detected in a few of the samples, and where present, were found in concentrations well below current exposure limits. Produced Under this Project Scientific Publications Assessment of N-nitrosodimethylamine DNA adducts by high performance liquid chromatography and immunosorbent assayFadlallah S., Cooper S. F., Lachapelle M., Denizeau F., Guertin F., Krzystyniak K., Fournier M.Source : International Journal of Environmental and Analytical Chemistry, vol. 56, 1994, p. 165-1746-methylguanine-DNA adducts in rat lymphocytes after in vivo exposure to N-nithroso-dimethylamine (NDMA) assessment of N-nitrosodimethylamineFadlallah S., Lachapelle M., Cooper S. F., Guertin F., Denizeau F., Krzystyniak K., Fournier M.Source : International Journal of Immunopharmacology, vol. 16, 1994, p. 583-591N-nitro compound in the ambient air of metal factories using metal-working fluidsFadlallah S., Cooper S. F., Perrault G., Truchon G., Lesage J.Source : Bulletin of Environmental Contamination and Toxicology, vol. 57, no 6, 1996, p. 867-874Presence of n-nitrosodiethanolamine contamination in Canadian metal-working fluidsFadlallah S., Cooper S. F., Perrault G., Truchon G., Lesage J.Source : Science of the Total Environment, vol. 196, no 3, 1997, p. 197-204Determination of N-Nitroso compounds in the environment of a metal factory Using metalworking fluidsFadlallah S., Cooper S. F., Fournier M., Drolet D., Perrault G.Source : International Journal of Environmental Analytical Chemistry, vol. 39, 1990, p. 281-288Determination of N-Nitroso compounds in metalworking fluidsFadlallah S., Cooper S. F., Fournier M., Drolet D., Perrault G.Source : Journal of Chromatographic Science, vol. 28, 1990, p. 517-523Identification de composés cancérigènes N-nitroso dans l'environnement des usines de métauxFadlallah S., Cooper S., Drolet D., Perrault G., Fournier M.Source : in Congrès de l'Association canadienne-française pour l'avancement des sciences / ACFAS, (53e : mai 1985 : Chicoutimi, Canada), 1985Détection et identification des composés N-nitroso dans les industries de métauxFadlallah S., Cooper S., Drolet D., Perrault G.Source : in Congrès de l'institut de chimie du Canada, (67e : juin 1984 : Montréal, Canada), 1984 Additional Information Type: Project Number: 0092-0470 Status: Completed Year of completion: 1996 Research Field: Chemical and Biological Hazard Prevention Team: Sam Cooper (Institut national de la recherche scientifique-Santé)Guy Perrault (IRSST)