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Project IRSST

Induced sputum analysis in silicosis and asbestosis: correlation with pulmonary functionLouis-Philippe Boulet, Marc Desmeules, Philippe Prince, Marie-Ève Boulay, Johane Lepage, Mylène Bertrand / Centre de recherche de l'IUCPQ


0099-2280 : Completed

Asbestosis and silicosis are the most common pneumoconioses in Québec and are often associated with a gradual deterioration in pulmonary function. The authors of this publication studied the possible role of induced expectoration (IE), a non-invasive technique for analyzing bronchial inflammation, in evaluating the severity of pneumoconioses and a decline in pulmonary function. They wanted to verify whether some markers of the inflammatory and fibrosis processes can be measured in IE and whether they are predictors of clinical evolution.
The authors believe that their findings will have to be verified on a larger number of workers, but that induced expectoration could be used to evaluate workers and to follow subjects at risk.



IRSST publications
Boulet, Louis-Philippe; Prince, Philippe; Desmeules, Marc
Analyse de l'expectoration induite dans la silicose et l'amiantose : corrélation avec la fonction pulmonaire   (Analysis of induced expectoration in silicosis and asbestosis: correlation with pulmonary function)
Études et recherches / Rapport  R-450, Montréal, IRSST, 2006, 33 pages. Free download   More Info

Scientific publications and communicationsPrince P.,  Boulay M. E.,  Desmeules M.,  Boulet L. P. 
Loss of pulmonary function in asbestosis and silicosis: correlation with airway inflammation
in American Thoracic Society International Conference : ATS 2006 (May 19-24, 2006, San Diego, USA), 2006, p. A656.

Prince P.,  Boulay M. E.,  Desmeules M.,  Boulet L. P. 
Pro-fibrotic cytokines in induced sputum of workers with asbestosis and silicosis: correlation with pulmonary function
in American Thoracic Society International Conference : ATS 2006 (May 19-24, 2006, San Diego, USA), 2006, p. A656.

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