Induced expectoration as a more sensitive non-invasive method for the laboratory diagnosis of occupational asthma

Abstract

In Quebec, occupational asthma is widespread and is the most common occupational respiratory disease. This condition is diagnosed through bronchial challenge tests, conducted in hospital laboratories. Bronchial inflammation is one of the characteristic features of asthma in general and occupational asthma in particular. This project investigated the effectiveness of induced expectoration, a recently developed non-invasive diagnostic method that reflects bronchial inflammation, and compared its diagnostic sensitivity to that of bronchial challenge tests. Tests conducted with subjects suffering from occupational asthma revealed that the new method detects bronchial inflammation even when respiratory function appears unaffected.

Produced Under this Project

Scientific Reports

Induced expectoration as a non-invasive means of improving the sensitivity of asthma diagnoses in hospital laboratories Research Report: R-254

Scientific Publications

Usefulness of induced sputum in the investigation of occupational ashtma using specific inhalation challenges
Lemière C., L'Archevêque J., Trudeau C., Patry N., Martin J. G., Cartier A., Malo J.-L.
Source :
American Journal of Respiratory and Critical Care Medecine, vol. 159, no 3, Part 2, March 1999, p. A233
Characterization of Airway Inflammation after Repeated Exposures to Occupational Agents
Lemière C., Chaboilliez S., Trudeau C., Taha R., Maghni K., Martin J. G., Hamid Q.
Source :
Journal of Allergy and Clinical Immunology, vol. 106, no 6, December 2000, p. p1163-p1170
Kinetics of inflammatory indices following exposure to occupational agents
Lemière C., Chaboillez S., Trudeau C., Taha R., Martin J. G., Hamid Q.
Source :
European Respiratory Journal, vol. 16, 2000, p. 158-ss

Additional Information

Type: Project

Number: 0097-0750

Status: Completed

Year of completion: 2000

Research Field: Chemical and Biological Hazard Prevention

Team:

Catherine Lemière (Hôpital du Sacré-Coeur)
André Cartier (Hôpital du Sacré-Coeur)
Jean-Luc Malo (Hôpital du Sacré-Coeur)