Hepatotoxicity due to mixed occupational exposure to solvents Abstract Halogenated hydrocarbons (haloalkanes) are recognized hepatotoxins. Other solvents used in conjunction with haloalkanes may increase the risk of liver damage. It is therefore necessary to identify harmful solvent-haloalkane interactions.Enzyme activity was used as an index of toxicity in rats administered ketone-based solvents orally (pre-treatment), and subsequently receiving haloalkane injections.Very small quantities of solvents such as acetone increase the harmful effects of haloalkanes. Long-chain molecules are particularly effective in this regard.Since this study is concerned with acute exposure, further studies of the effects of repeated exposure, similar to that experienced in the workplace, is indicated. The identification of the least dangerous solvents would also be useful. The IRSST has funded a subsequent project concerning this last point (RS-83-10). Produced Under this Project Scientific Reports Expected effects of hepatotoxic interactions in industrial workers exposed to organic solvents Research Summary: PR-005 Scientific Publications Potentiation of liver and kidney injury by ketones and ketogenic substancesPlaa G. L., Hewitt W. R.Source : Advances in Pharmacology and Therapeutics II, vol. 5, H. Yoshida, Y. Hagihara, S. Ebashi (ed.)., New York, N.Y., Pergamon Press, 1982, p. 65-75Isopropanol and acetone potentiation of carbon tetrachloride-induced hepatotoxicity: Single versus repetitive pretreatments in ratsPlaa G. L., Hewitt W. R., Du Souich P., Caillé G., Lock S.Source : Journal of Toxicology and Environmental Health, vol. 9, 1982, p. 235-250 Additional Information Type: Project Number: 0080-0030 Status: Completed Year of completion: 1982 Research Field: Chemical and Biological Hazard Prevention Team: Gabriel Plaa (Université de Montréal)