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Research project

Prevention of chemical and biological hazards

Effect of chemical substances on hearing: interactions with noise

Adolf Vyskocil / Université de Montréal
Ginette Truchon / IRSST
Tony Leroux, Claude Viau / Université de Montréal



0099-7450 : Completed

While noise is the main cause of occupational deafness, certain chemical substances can produce ototoxic effects that may make the ear more prone to acoustic assault, as opposed to noise alone. They are mainly solvents, asphyxiants, metals and pesticides, widespread in workplaces. In Quebec, over 400,000 workers are exposed to high noise levels, which raises concerns regarding the prevention of hearing impairments. After having evaluated the effects of chemical substances alone on hearing, this time, researchers will analyze literature data to characterize the interactions between these chemical substances and noise, at exposure levels respecting the current standards of the Regulation respecting occupational health and safety. The results of this study will make it possible to determine the ototoxic agents that are most likely to interact with noise and to propose prevention strategies to stakeholders that take into account the additivity risk of the effects on hearing in situations of simultaneous exposure.



IRSST publications


Vyskocil, Adolf; Leroux, Tony; Truchon, Ginette; Lemay, François; Gagnon, France; Gendron, Martine; Boudjerida, Amar; El-Majidi, Maïma; Viau, Claude
Effect of Chemical Substances on Hearing: Interactions with Noise
Studies and Research Projects / Report  R-747, Montréal, IRSST, 2012, 44 pages. Free download   More Info


Vyskocil, Adolf; Leroux, Tony; Truchon, Ginette; Lemay, François; Gagnon, France; Gendron, Martine; Boudjerida, Amar; El-Majidi, Naïma; Viau, Claude
Effet des substances chimiques sur l’audition - Interactions avec le bruit   (Effect of chemical substances on hearing: interactions with noise)
Études et recherches / Rapport  R-685, Montréal, IRSST, 2011, 44 pages. Free download   More Info

Scientific publications and communications


Leroux T.,  Vyskocil A.,  Truchon G. ,  Lemay F.,  Gagnon F.,  Gendron M.,  Boudjerida A.,  El-Majidi N.,  Viau C. 
The weight of evidence approach in the assessment of hearing impairment induced by noise and ototoxic chemicals
in Proceedings of the 10th International Congress on Noise as a Public Health Problem / ICBEN 2011, (10th : July 24-28, 2011 : London, UK), 2011.

Leroux T.,  Vyskocil A.,  Truchon G. ,  Gendron M.,  Lemay F.,  Lim S.,  Gagnon F.,  Viau C. 
The weight of evidence approach in the case of ototoxic chemicals
in Annual Hearing Conservation Conference : Explore the World of Hearing Loss Prevention / NHCA 2010 (35th : February 27-27, 2010 : Orlando, USA), 2010.

Vyskocil A.,  Truchon G. ,  Leroux T.,  Lemay F.,  Gendron M.,  Lim S.,  Gagnon F.,  Viau C. 
A weight of evidence approach for the assessment of the ototoxic potential of industrial chemicals
Toxicology and Industrial Health, vol. 28, no 9, 2012, p. 796-819.

Vyskocil A.,  Lemay F.,  Leroux T.,  Gagnon F.,  Gendron M.,  Boudjerida A.,  Truchon G. ,  Lim S.,  Viau C. 
Ototoxic effects of industrial chemicals alone or in combination with noise
in Health, Work and Social Responsibility : IOHA 2010 : International Scientific Conference (8th : September 28 - October 2, 2010 : Roma, Italy), 2010.

Vyskocil A.,  Lemay F.,  Leroux T.,  Gagnon F.,  Gendron M.,  Boudjerida A.,  Truchon G. ,  El Majidi N.,  Lim S.,  Viau C. 
Assessment of hearing dysfunction induced by industrial chemicals in presence or absence of noise: a weight of evidence approach (Poster)
in British Toxicology Society Annual Congress / BTS, (March 28-31, 2010 : Edinburgh, Scotland), 2010.

Vyskocil A.,  Leroux T.,  Truchon G. ,  Lemay F.,  Gendron M.,  Gagnon F.,  El Majidi N.,  Viau C. 
The assessment of the ototoxic potential of ethyl benzene
in Toxicology Letters - Eurotox 2009 : 46th Congress of The European Societies of Toxicology (46th : September 13-16, 2009 : Dresden, Germany), vol. 189, suppl. 1, 2009, p. S257.

Vyskocil A.,  Leroux T.,  Truchon G. ,  Lemay F. ,  Gagnon F.,  El Majidi N.,  Viau C. 
Occupational ototoxicity of ethyl benzene (Poster)
in Proceedings of the 29th International Congress on Occupational Health / ICOH, (29th : March 22-27, 2009 : Cape Town, South Africa), 2009.

Videos

11:21

Effect of chemical substances on hearing: interactions with noise

Research results presentations (2010)

(In French only)

While noise is the main cause of occupational deafness, certain chemical substances can produce ototoxic effects that may make the ear more prone to acoustic assault, as opposed to noise alone. They are mainly solvents, asphyxiants, metals ...

Claude Viau,  professeur, Université de Montréal



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