Development and validation of a bronchial challenge protocol for gaseous occupational exposures Abstract Thanks to clinical bronchial challenge tests, occupational asthma is being diagnosed with increasing frequency. In Québec, the incidence of occupational asthma is greater than that of asbestosis and silicosis combined. Over the past two years, the research team developed an exposure method for particles and gaseous isocyanates and now wants to extend it to other gaseous contaminants. Clinical validation of the organic compound vapour exposure system was performed at the Pneumology Unit of Hôpital du Sacré-Coeur, using formaldehyde and ethanolamine on 10 to 20 subjects referred for diagnosis of occupational asthma. The equipment and method developed will allow hospital laboratories to perform specific bronchial challenge tests of any gaseous occupational contaminant, with no risk to subjects or hospital personnel. In addition, the system will facilitate the strict control of exposure levels and establishment of dose-response curves, and hence leading-edge data on the diagnosis of occupational asthma. Produced Under this Project Scientific Reports Development and validation of a bronchial challenge test methodology for work-related substances in vapour form Research Report: R-153 Scientific Publications Mise au point technique d'un système de génération du glutaraldéhyde pour le diagnostic médical dans le domaine de l'asthme professionnelBélanger J.Source : in Le partenariat en santé et sécurité du travail: une approche à développer : Congrès de l'Association québécoise pour l'hygiène, la santé et la sécurité du travail / AQHSST, (18e : mai, 1996 : Hull, Canada), 1996, p. 31Closed-circuit apparatus for specific inhalation challenges with an occupational agents in vapour form : FormaldehydeLemière C., Cloutier Y., Perrault G., Drolet D., Cartier A., Malo J.-L.Source : Chest, vol. 109, no 6, 1996, p. 1631-1635Occupational asthma due to formaldehyde resin dust without reaction to formaldehyde gasLemiere C., Desjardins A., Cloutier Y., Drolet D., Perrault G., Cartier A., Malo J.-L.Source : European Respiratory Journal, vol. 8, no 5, 1995, p. 861-865Asthma in the workplaceLesage J., Perrault G.Source : Environmental Monitoring of Chemical Agents, Marcel Dekker Inc., New York, 1993, p. 277-299Device for specific inhalation challenge, method of use and improved generator of particules / Dispositif conçu pour certains tests respiratoires, méthode d'utilisation et générateur de particules amélioréCloutier Y.Source : Institut de recherche en santé et en sécurité du travail du Québec / IRSST, 4 mai 1993, Classe canadienne : 128/71 137/1.511, Classe internationale : A61H 31/00, Brevet no 1317194, CanadaDevice for specific inhalation challenge, method of use and improved generator of particlesCloutier Y.Source : Institut de recherche en santé et en sécurité du travail du Québec / IRSST, mai 1989, Brevet no 601235, États-Unis Additional Information Type: Project Number: 0090-1290 Status: Completed Research Field: Chemical and Biological Hazard Prevention Team: Jean-Luc Malo (Hôpital du Sacré-Coeur)André Cartier (Hôpital du Sacré-Coeur)Guy Perrault (IRSST)