Development and improvement of a dust exposure and monitoring system for bronchial challenge tests Abstract Diagnosis of occupational asthma, currently the most prevalent occupational lung disease, involves specific bronchial challenge tests. However, the Pepys aerosol-generation technique, presently used in these tests, does not produce well-controlled exposure conditions.An aerosol-generation system was designed at the IRSST and evaluated by a Montréal-area hospital in 21 patients suspected of suffering from occupational asthma caused by a variety of substances (e.g. red cedar, psyllium, guar gum).Aerosol concentrations generated by this system were stable. Dose-response curves were established for aerosol concentration and bronchial response.The system developed here will permit occupational asthma to be studied under safer conditions and with more rigour. The system used to generate standardized exposures is marketable throughout the industrialized world. Produced Under this Project Scientific Reports Development and validation of a bronchial challenge test methodology by dust inhalation Research Summary: PR-100 Scientific Publications Validation of an exposure system to particles for the diagnosis of occupational asthmaCloutier Y., Lagier F., Cartier A., Malo J.-L.Source : Chest, vol. 102, no 2, 1992, p. 402-407Response to isocyanates: Effects of concentration duration of exposure and doseVandenplas O., Cartier A., Ghezzo H., Cloutier Y.Source : American Review of Respiratory Diseases, vol. 147, 1993, p. 1287-1290New methodology for specific inhalation chalenges with occupational agents in powder formCloutier Y., Lagier F., Lemieux R., Blais M. C., Saint-Arnaud C., Cartier A., Malo J.-L.Source : European Respiratory Journal, vol. 2, 1989, p. 769-777Computerized equipment for the delivery of inhaled doses of solid particles in specific bronchial challengeFabriès J.-F., Choudat D., Wrobel R., Cloutier Y., Dessandes J.-F., Villette C., Dallava J., Conso F.Source : Journal of Aerosol Medicine, vol. 13, no 1, 2000, p. 1-10Closed-circuit methodology for inhalation challenge tests with isocyanatesBoutet M., Boulet L.-P., Malo J.-L., Cartier A., Leblanc C., Milot J., Laviolette M.Source : American Review of Respiratory Disease, vol. 145, no 3, 1992, p. 582-587Acute exposure to sawdust does not alter airway calibre and responsiveness to histamine in asthmatic subjectsDe Luca S., Caire N., Cloutier Y., Cartier A., Ghezzo H., Malo J. L.Source : European Respiratory Journal, vol. 1, no 6, 1988, p. 540-546Acute exposure to an occupational irritant agent does not significantly alter bronchial responsiveness to histamine in asthmatic subjectsDe Luca S., Caire N., Cloutier Y., Ghezzo H., Cartier A., Malo J. L.Source : in International Conference of the American Thoracic Society (May 10-13, 1987 : New Orleans, Louisiana), 1987Nouvelle méthodologie de tests de provocation bronchique spécifique par génération de poussières dans le diagnostic de l'asthmeLagier F., Malo J. L., Cartier A., Cloutier Y.Source : in Congrès international de pneumologie, (4-7 juin, 1989 : Alger, Algérie), 1989Investigating occupational asthma using a new aerosolization device for specific challengesMalo J.-L., Cartier A., Lagier F., Cloutier Y.Source : in 1st Canadian Aerobiological Conference, (1st : June 1988 : Montreal, Canada), 1988Validation of a new aerolization device for specific inhalation challenges with agents in powder from in the diagnosis of occupational asthmaMalo J. L., Cartier A., Lagier F., Cloutier Y.Source : in Fourth International Conference on Environmental Lung Disease (4th : September 25-28, 1991 : Montreal, Canada), 1991New methodology for inhalation challenges with isocyanatesMalo J. L., Cloutier Y., Cartier A., Vandenplas O., Perrin B., Trudeau C.Source : in The American Academy of Allergy and Immunology, forty-seven annual meeting, (47th : March 1-6, 1991Technical update of an exposure system to particles for the diagnosis of occupational asthmaCloutier Y., Malo J. L.Source : in Fourth International Conference on Environmental Lung Disease (4th : September 25-28, 1991 : Montreal, Canada), 1991L'exposition aigue à un agent professionnel irritant ne change pas l'hyperexcitabilité bronchique à l'histamine de sujets asthmatiquesCaire N., De Luca S., Cloutier Y., Ghezzo H., Cartier A., Malo J. L.Source : in Club de recherches cliniques (19-31 octobre, 1987 : Québec, Canada), 1987 Additional Information Type: Project Number: 0087-0110 Status: Completed Research Field: Unclassified Team: Yves Cloutier (IRSST)Jean-Luc Malo (Hôpital du Sacré-Coeur)André Cartier (Hôpital du Sacré-Coeur)