Analysis of the biological mechanism of action of inhaled silicon carbide fibres Abstract Fibre exposure of workers in silicon carbide plants is poorly understood.The toxicity and effects of several components of workplace dust were studied in sheep, using bronchioalveolar lavage and analysis of lung autopsy tissue.All dusts found in the plant, with the exception of quartz, were harmless, and all fibres, regardless of their graphite content, caused fibrosis reminiscent of asbestosis.Monitoring procedures similar to those used in asbestos mines should be implemented in silicon carbide plants. Produced Under this Project Scientific Reports Biological action mechanisms of inhaled silicon carbide fibers Research Summary: PR-106 Scientific Publications Carborundum pneumoconiosis : biological mechanismsBégin R., Cantin A., Sébastien P., Dufresne A., Perrault G., Massé S.Source : in American Thoracic Society, American Lung Association, Annual Meeting, (1988 : Las Vegas, Nevada), American Review of Respiratory Disease, vol. 137, no 4, partie 2, avril 1988, p. 353La pneumoconiose du carborundum : mécanismes biologiquesBégin R., Cantin A., Sébastien P., Dufresne A., Perrault G., Massé S.Source : Revue des maladies respiratoires, vol. 2, 1988, p. 31Carborundum pneumoconiosisBégin R., Dufresne A., Cantin A., Massé P., Sébastien P., Perrault G.Source : Chest, vol. 95, 1989, p. 842-849 Additional Information Type: Project Number: 0085-0090 Status: Completed Year of completion: 1987 Research Field: Chemical and Biological Hazard Prevention Team: Raymond Bégin (Université de Sherbrooke)Guy Perrault (IRSST)