Summary Rationale for the “Éleveurs de porcs en santé” (healthy pork producers) study Canada’s occupational health and safety record in the agricultural sector is worrisome. Although in recent years there has been a significant reduction in agriculture-related deaths, the cumulative empirical evidence shows that this sector remains risky in terms of other indicators of interest (such as physical and mental health, safe work practices). However, few studies in the Canadian context have examined multiple individual and environmental determinants (i.e., the immediate work environment and its interface with the family, the farming and agricultural production sector) in order to explain these occupational health and safety indicators in a single population of agricultural producers. With this in mind, the general objective of the healthy pork producers study is to document the determinants of agricultural health and safety that reflect the current situation of Québec pork producers. There are three specific objectives: Objective 1: Outline the key occupational health and safety issues (physical and mental health, safe work practices) faced by Québec pork producers. Objective 2: Describe the nature of the determinants (i.e., individual characteristics of producers, immediate work environment and its interface with the family and the organizational environment of the farm enterprise) of the occupational health and safety indicators examined. Objective 3: Develop a scale to measure the occupational demands and resources resulting from the implementation of quality assurance and animal welfare programs and assess their added value as determinants of the occupational health and safety of producers. How the study was conducted This study, conducted in partnership with the Québec pork producers’ association (Éleveurs de porcs du Québec), used a multi-method cross-sectional research design. The first phase took place in 2020 with 20 hog farmers, who shared their views on occupational health and safety and the impact of quality assurance and animal welfare programs on their day-to-day work through semi-structured interviews. A second phase, in 2021, was based on a survey mailed out to 400 hog farms, members of the Beauce, Deux Rives and Monterégie regional unions, and selected at random. A total of 182 individuals responded to the survey on the determinants of occupational health and safety for pork producers. Main results The study provides important insights into the range of occupational health and safety issues faced by pork producers (Objective 1). Among the issues most frequently documented in the study’s survey were that almost one in six producers reported a workplace accident in the past year, one in two producers suffered from low-back musculoskeletal disorders, and one in three producers experienced high levels of psychological distress. Moreover, although some work practices that pose a risk to occupational safety are occasionally or frequently adopted (e.g., doing maintenance alone in confined spaces), other work practices that could improve it are also mentioned (e.g., keeping abreast of new information to improve occupational health and safety on the farm). Several of these issues were identified as priorities by the farmers during the semi-structured interviews. The occupational demands of the immediate work environment (i.e., cumulative physical strain, workload, conflictual relationships with partners, work-family conflict) were risk factors for more than one of the occupational health and safety indicators assessed in the survey (i.e., accidents and near misses at work, musculoskeletal disorders, safe work practices, psychological stress and distress). On the other hand, farm enterprise occupational resources (such as investment in OHS) also emerged as protective factors for other indicators (i.e., accidents, safe work practices) (Objective 2). A full psychometric evaluation of the measurement scale on occupational demands and resources associated with quality assurance and animal welfare confirms its validity (Objective 3). Preliminary results indicate that these occupational demands and resources help to explain farmers’ health (i.e., psychological stress, musculoskeletal disorders affecting the lower back). Main benefits for research and practice settings The healthy pork producers study benefits research by highlighting a number of avenues that will advance knowledge in agricultural health and safety. By considering the environmental determinants of agricultural health and safety from a multifactorial (i.e., occupational demands and resources) and multilevel (i.e., immediate work environment and its interface with the family, farming and agricultural production sector) perspective within the same integrative model, the study strengthens the theoretical and empirical basis for exploring some of the less-investigated analytical links. In terms of practical benefits, the results of the study underscore the potential for knowledge transfer to agricultural producers and stakeholders involved in occupational health and safety. The study enhances understanding of the agricultural health and safety determinants likely to enrich existing secondary and tertiary actions targeting all agricultural producers in Québec. In addition, the results support the relevance of positioning quality assurance and animal welfare programs, and their knowledge transfer mechanisms in particular, as additional levers for OHS risk prevention in the pork production sector.