Studying the environmental and physiological factors contributing to biological variability: impact of workload on biological exposure indicators Abstract A research program undertaken by the IRSST a few years ago showed that workload can have a major impact on the value of the biological exposure indicators (BEI) for various solvents. During a subsequent step, the researchers were able to better characterize this impact. Using volunteers, they studied in the laboratory the variations in the BEIs induced by different workloads for five industrial solvents and under exposure conditions similar to those prevailing in an industrial environment. For four of the five solvents studied (toluene, styrene, trichloroethylene and acetone), an increase in workload produced an increase in the biological exposure indicators, in contrast to n-hexane, whose BEIs remained stable. Physiologically-based toxicokinetic (PBTK) modeling, developed for each of the solvents, corroborates these results.Designers of PBTK models now have equations resulting from probative physiological data that they can use to integrate variability in the workload into their model. Produced Under this Project Scientific Reports Impact of workload on the biological exposure indicators for five solvents Research Report: R-561 Scientific Publications Évaluation de l’impact exercé par la charge de travail sur les indicateurs biologiques d’exposition du toluène suite à des expositions par inhalation chez des volontairesNadeau V., Truchon G., Brochu M., Tardif R.Source : in La société des savoirs : 72e Congrès de l'Association canadienne-française pour l'avancement des sciences / ACFAS (72e : 10-14 mai, 2004 : Montréal, Canada), 2004Effect of workload on the kinetics of inhaled toluene in human volunteersNadeau V., Truchon G., Brochu M., Tardif R.Source : in American College of Sports Medicine Annual Meeting (51st : June 2-5, 2004 : Indianapolis, Indiana), 2004Effect of physical exertion on the biological exposure indices ot toluene following exposure by inhalation in human volunteersNadeau V., Truchon G., Brochu M., Tardif R.Source : in Proceedings of the Annual Meeting of the Society of Toxicology (43rd : March 21-25, 2004 : Baltimore, Maryland), 2004Effect of physical exertion on the biological exposure indices of various solvents following exposure by inhalation in human volunteers : I. Toluene Nadeau V., Truchon G., Brochu M., Tardif R.Source : Journal of Occupational and Environmental Hygiene, vol. 3, no 9, 2006, p. 481-489Effect of physical exertion on the biological monitoring of exposure to solvents in human volunteers : 2. n-HexaneTardif R., Nadeau V., Truchon G., Charest-Tardif G., Brochu M.Source : in Proceedings of the 28th International Congress on Occupational Health / ICOH, (28th : June 11-16, 2006 : Milan, Italy), 2006Effect of physical exertion on the biological monitoring of exposure to solvents in human volunteers : 1. TolueneTardif R., Nadeau V., Truchon G., Charest-Tardif G., Brochu M.Source : in Proceedings of the 28th International Congress on Occupational Health / ICOH, (28th : June 11-16, 2006 : Milan, Italy), 2006Effect of physical exertion on the biological monitoring of exposure to various solvents following exposure by inhalation in human volunteers: II. n-HexaneTardif R., Nadeau V., Truchon G., Brochu M.Source : Journal of Occupational and Environmental Hygiene, vol. 4, no 7, 2007, p. 502-508Effect of physical exertion on the biological monitoring of exposure to various solvents following exposure by inhalation in human volunteers: III. StyreneTruchon G., Brochu M., Tardif R.Source : Journal of Occupational and Environmental Hygiene, vol. 6, no 8, 2009, p. 460-467Modeling the impact of workload intensity on the biological exposure indicators of solventsTardif R., Truchon G., Bérubé A., Sari-Minodier I., Charest-Tardif G.Source : in International Congress of Toxicology / IUTOX (12th : July 19-23, 2010 : Barcelona, Spain), 2010 Additional Information Type: Project Number: 0099-1700 Status: Completed Year of completion: 2008 Research Field: Chemical and Biological Hazard Prevention Team: Ginette Truchon (IRSST)Robert Tardif (Université de Montréal)Phillip Gardiner (Université de Montréal)Martin Brochu (Université de Montréal)