Biological monitoring of firefighter exposure to benzo(a)pyrene (BaP) and aromatic amines during a fire at a tire dump Abstract Firefighters involved in extinguishing a fire at a tire dump in Saint-Amable may have suffered acute or subacute exposure to benzo(a)pyrene or aromatic amines. Although such exposure is almost impossible to evaluate from environmental measurements, it appears feasible to evaluate it through the measurement of protein adducts, complexes formed between certain toxic products or their metabolites and molecules occurring naturally in the body. The blood concentrations of protein adducts was measured in exposed firefighters and a group of unexposed matched controls. The results revealed low exposure to benzo(a)pyrene and exposure to aromatic amines at concentrations significantly higher than background levels. The concentration of aromatic amine adducts in exposed firefighters did not differ from that in controls seven months after exposure, indicating elimination of these substances during this period. Produced Under this Project Scientific Reports Biological monitoring of fire fighter exposure to benzo(a)pyrene and aromatic amines following a fire in a tire dump Research Report: R-184 Scientific Publications Improved procedure for the high-performance liquid chromatographic determination of monohydroxylated PAH metabolites in urineBouchard M., Dodd C., Viau C.Source : Journal of Analytical Toxicology, vol. 18, 1994, p. 261-264Benzo(a)pyrenediolepoxide-hemoglobin adducts and 3-hydroxybenzo(a)pyrene urinary excretion profiles in rats subchronically exposed to benzo(a)pyreneBouchard M., Viau C.Source : Archives of Toxicology, vol. 69, no 8, 1995, p. 540-546Kinetics of hemoglobin and albumin adducts in rabbits subchronically exposed to benzo(a)pyreneViau C., Carrier G.Source : Fundamental and Applied Toxicology, vol. 24, 1995, p. 140-144Patterns of 1-hydroxypyrene excretion in volunteers exposed to pyrene by the dermal routeViau C., Vyskocil A.Source : The Science of the Total Environment, vol. 163, 1995, p. 187-190 Additional Information Type: Project Number: 0091-1410 Status: Completed Year of completion: 1995 Research Field: Chemical and Biological Hazard Prevention Team: Claude Viau (Université de Montréal)Claude Tremblay (Hôpital Charles-Lemoyne)Ben Armstrong (Université McGill)Michel Bertrand (Université de Montréal)Jules Brodeur (Université de Montréal)Louis Jacques (Hôpital Charles-Lemoyne)