Occupational exposures and reproductive functions of males: state of knowledge Abstract Numerous studies report a slight reduction in fertility in men in the last century, and several reasons have been given. An exploratory study carried out in Estrie, linking occupational exposures and infertility problems in CHUS fertility clinic patients has established a link between these problems and work in the manufacturing sector. There is therefore a reason for further exploration of this research avenue.The objective of this study is to carry out a systematic and critical review of existing scientific studies on the relationship between occupational exposures to regulated contaminants in Québec and male fertility. This literature review will allow the relevance of studying this issue to be evaluated and the research orientations to be defined. Produced Under this Project Scientific Publications Electron microscopy analysis of histone acetylation and DNA strand breaks in mouse elongating spermatids using a dual labelling approachBikond Nkoma G., Leduc F., Jouad L., Boissonneault G.Source : Andrologia, vol. 42, no 5, 2010, p. 322-325The sperm nucleus: chromatin, RNA, and the nuclear matrixJohnson G. D., Lalancette C., Linnemann A. K., Leduc F., Boisonneault G., Krawetz S. A.Source : Reproduction, vol. 141, no 1 , 2011, p. 21-36Spermiogenesis in Sperm Genetic Integrity Grégoire M.-C., Leduc F., Boissonneault G.Source : in Sperm chromatin: biological and clinical application in male infertility and assisted reproduction, Zini, A., Argawa, A. (éds), Springer, 2011, chapter 21Epigenetic contribution to the genetic instability of haploid male germ cellsLeroux J., Arguin M., Acteau G., Boissonneault G.Source : in Innovations in Gender, Sex, and Health Research Conference (November 21-22, 2010 : Toronto, Canada), 2010Epidenetic contribution to the genetic instability of haploid male germ cellsLeroux J., Arguin M., Acteau G., Boissonneault G.Source : in Symposium du Réseau québécois en reproduction / RQR (3e : 16-17 novembre, 2010 : Québec, Canada), 2010Identification of the DNA damage response pathway to endogenous strand breaks in spermatids as a new male-driven source of genetic instabilityActeau G., Carrier-Leclerc A., Leduc F., Simard O., Arguin M., Boissonneault G.Source : in Symposium du Réseau québécois en reproduction / RQR (3e : 16-17 novembre, 2010 : Québec, Canada), 2010The DNA repair pathway in spermatids, a possible cause of male infertilityCarrier-Leclerc A., Acteau G., Leduc F., Arguin A., Boissonneault G.Source : in Innovations in Gender, Sex, and Health Research Conference (November 21-22, 2010 : Toronto, Canada), 2010 Additional Information Type: Project Number: 0099-8740 Status: Completed Year of completion: 2013 Research Field: Chemical and Biological Hazard Prevention Team: Larissa Takser (Université de Sherbrooke)Guylain Boissonneault (Université de Sherbrooke)