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Project IRSST
 | Impact of Toxicological Interactions on the Management of Exposure to Multiple ContaminantsAdolf Vyskocil
/ Université de Montréal
Daniel Drolet
/ IRSST
Michel Gérin,
Denis Bégin
/ Université de Montréal
François Lemay
/ IRSST
Jules Brodeur,
Robert Tardif,
Claude Viau
/ Université de Montréal
Ginette Truchon,
Marc Baril
/ IRSST
Gilles Lapointe
/ Commission de la santé et de la sécurité du travail
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0099-0730 : Completed
Criteria related to exposure to multiple contaminants does not usually take into account possible interactions and, therefore, possible changes in their toxicity. In phase two of this project, researchers will explain the potential interactions of substances used in the workplace that are already controlled and documented. They will then propose a method for calculating the response of the human body, to determine whether or not the adjusted mean exposure value of the combination of these substances has been exceeded, and develop a questionnnaire regarding possible interactions. Using the information from this database, it will be possible to make qualitative judgements, for each known situation, on the nature of contaminant interaction and on the health effects of the contaminants. Integrated into the CSST's Toxicological Index, this data will be useful to occupational health and safety stakeholders and can also be disseminated on the Internet.
IRSST publicationsVyskocil, Adolf; Viau, Claude; Tardif, Robert; Bégin, Denis; Gérin, Michel; Gagnon, France; Drolet, Daniel; Lemay, François; Truchon, Ginette; Baril, Marc; Lapointe, Gilles; Gagnon, NormandImpact des interactions toxicologiques sur la gestion des situations d’exposition à des contaminants multiples
(Impact of toxicological interactions on the management of multiple contaminant exposure situations)
Études et recherches / Rapport
R-425, Montréal, IRSST, 2005, 46 pages. Free download
More Info
Scientific publications and communicationsBorska L.,
Fiala Z.,
Borsky T.,
Vyskocil A.,
Kremlacek J.
Risk evaluation of multichemical exposures at industrial emergencies
in International Symposium on Toxicity Assessment, (12th : June 12-17, 2005 : Skiatos Island, Greece), 2005.
Drolet D.,
Lemay F.,
Truchon G.,
Baril M.,
Vyskocil A.,
Viau C.,
Tardif R.,
Bégin D.,
Gérin M.,
Gagnon N.,
Lapointe G.
A Web-based tool for the management of the toxicological risk of chemical mixtures
in American Industrial Hygiene Conference and Exhibition / AIHCE, (May 21-26, 2005 : Anaheim, California), 2005.
Drolet D.,
Vyskocil A.,
Lemay F.,
Viau C.,
Lapointe G.,
Tardif R.,
Truchon G.,
Baril M.,
Gagnon N.,
Bégin D.,
Gagnon F.,
Gérin M.
Interactions toxicologiques en milieu de travail : un outil Web d'aide à la décision pour la gestion du risque
in La SST de la pratique à l’intégration…un défi ! : 27e congrès de l’Association québécoise pour l’hygiène, la santé et la sécurité du travail / AQHSST (27e : 17-19 mai, 2005 : St-Hyacinthe, Canada), 2005.
Drolet D.,
St-Jacques A.,
Simard S.
A computer tool to "vampirize" some occupational health and safety Web sites
in American Industrial Hygiene Conference and Exhibition / AIHCE, (May 21-26, 2005 : Anaheim, California), 2005.
Emond C.,
Lapointe C.,
Vyskocil A.
Interactions between chemicals and drugs in the workplace. Is there a cause for concern?
in Eurotox 2006 : 43rd Congress of The European Societies of Toxicology (September 20-24, 2006 : Dubronik, Croatia), Toxicology Letters, vol. 164S, 2006, no P6-10, p. S125-S126.
Fiala Z.,
Vyskocil A.,
Lemay F.,
Kremlacek J.,
Borska L.,
Drolet D.,
Borsky T.,
Viau C.
Application of software product "Mixie" for occupational health risk evaluation of exposure to mixtures of chemicals
Toxicology Letters, vol. 180, Suppl. 1, 2008, p. S145.
Fiala Z.,
Vyskocil A.,
Lemay F.,
Kremlacek J.,
Borska L.,
Drolet D.,
Borsky T.,
Viau C.
Health risk evaluation of exposure to mixtures of chemicals in occupational air
Chemicke Listy, vol. 101, 2007, p. S94-S96.
Fiala Z.,
Vyskocil A.,
Lemay F.,
Kremlacek J.,
Borska L.,
Drolet D.,
Borsky T.,
Viau C.
Occupational health risk evaluation of exposure to mixtures of chemicals
Toxicology Letters, vol. 172, suppl. 1, 2007, p. S115.
Fiala Z.,
Vyskocil A.,
Lemay F.,
Kremlacek J.,
Borska L.,
Drolet D.,
Borsky T.,
Viau C.
Health risk evaluation of exposure to mixtures of chemicals in occupational air
in Conference of Czech Society of Toxicology (June 11-13, 2007 : Prague), 2007.
Vyskocil A.,
El Majidi N.,
Lemay F.,
Viau C.,
Gagnon F.,
Tardif R.,
Drolet D.
Impact des interactions toxicologiques sur la gestion des situations d’exposition à des contaminants multiples
in "Santé au travail : nouvelles connaissances mobilisables" : rencontes scientifiques de l'Agence française de sécurité sanitaire de l'environnement et du travail / AFSSET, (7 mai, 2008 : Paris, France), 2008.
Vyskocil A.,
Drolet D.,
Viau C.,
Lemay F.,
Lapointe G.,
Tardif R.,
Truchon G.,
Baril M.,
Gagnon N.,
Gagnon F.,
Bégin D.,
Gérin M.
A web tool for the identification of potential interactive effects of chemical mixtures
Journal of Occupational and Environmental Hygiene, vol. 4, no 4, 2007, p. 281-287.
Vyskocil A.,
Drolet D.,
Lemay F.,
Viau C.,
Lapointe G.,
Tardif R.,
Truchon M.,
Baril M.,
Gagnon N.,
Bégin D.,
Gérin M.,
Gagnon F.
Assessment of the toxicological risk of chemical mixtures in the workplace (Affiche)
in Society of Toxicology Annual Meeting and ToxExpo (44th : March 6-10, 2005 : New Orleans, United States), 2005.
Vyskocil A.,
Drolet D.,
Viau C.,
Lemay F.,
Lapointe G.,
Tardif G.,
Truchon G.,
Baril M.,
Gagnon N.,
Gagnon F.,
Bégin D.,
Gérin M.
A database for the assessment of potential interactive effects of chemical mixtures at workplace
Toxicology Letters, vol. 15, suppl. 1, 2005, p. S75.
Vyskocil A.,
Drolet D.,
Viau C.,
Lemay F.,
Lapointe G.,
Tardif G.,
Truchon G.,
Baril M.,
Gagnon N.,
Bégin D.,
Gérin M.
Assessment of the toxicological risk of chemical mixtures at workplace
Toxicological Sciences, vol. 84, no 1-S, 2005, p. 244.
Vyskocil A.,
Drolet D.,
Lemay F.,
Viau C.,
Lapointe G.,
Tardif G.,
Truchon G.,
Baril M.,
Gagnon N.,
Bégin D.,
Gérin M.
A web tool for the identification of potential interactive effects of chemical mixtures
in Occupational Hygiene 2005 : British Occupational Hygiene Society Annual Conference (April 19-21, 2005 : Manchester, U.S.A.), 2005, p. 45.
Vyskocil A.,
Drolet D.,
Viau C.,
Brodeur J.,
Tardif R.,
Gérin M.,
Baril M.,
Truchon G.,
Lapointe G.
Database for the toxicological evaluation of mixtures in occupational atmospheres
Environmental Toxicology and Pharmacology, vol. 18, no 3, 2004, p. 235-242.
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