 | Évaluation de la toxicité du béryllium en fonction de la forme chimique et de la taille des particules(Evaluation of beryllium toxicity based on the chemical form and particle size
)Muller, Caroline; Mazer, Bruce; Salehi, Fariba; Audusseau, Séverine; Truchon, Ginette; Lambert, Jean; L Espérance, Gilles; Chevalier, Gaston; Suzanne, Philippe; Cloutier, Yves; Larivière, Pierre; Zayed, JosephÉtudes et recherches / Rapport
R-637, Montréal, IRSST, 2010, 60 pages. |
Abstract
In recent years, numerous authors have been questioning the level of protection offered to workers by the recognized threshold value for beryllium (Be) and its salts. The authors wanted to verify, using an animal model, to what extent pulmonary effects are related to the chemical form of Be and the size of its particles. The results obtained demonstrate numerous correlations between tissue concentrations of Be and pulmonary effects similar to those observed in a worker following exposure. The results also reveal an association between particle size, lung concentrations, pulmonary inflammation, the production of certain cytokines, and the expression of certain lymphocytes. The effects also depend on the chemical form of Be. Obviously, aerodynamic diameter and solubility played a significant role in pulmonary deposition and retention.
The results of this study contribute to the understanding of the role of particle size and chemical form in the toxicity of Be. As well, they help to guide preventive actions relating to Be exposure, possibly including review of the exposure limit and the establishment of limit values as a function of chemical form and particle size.
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